Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.46 |
| ▸ | PSMB11 | A5LHX3 | 4/20 | 0.43 |
| ▸ | PSMA7 | O14818 | 4/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 4/20 | 0.43 |
| ▸ | PSMA1 | P25786 | 4/20 | 0.43 |
| ▸ | PSMA2 | P25787 | 4/20 | 0.43 |
| ▸ | PSMA3 | P25788 | 4/20 | 0.43 |
| ▸ | PSMA4 | P25789 | 4/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.43 |
| ▸ | PSMB9 | P28065 | 4/20 | 0.43 |
| ▸ | PSMA5 | P28066 | 4/20 | 0.43 |
| ▸ | PSMB4 | P28070 | 4/20 | 0.43 |
| ▸ | PSMB6 | P28072 | 4/20 | 0.43 |
| ▸ | PSMB10 | P40306 | 4/20 | 0.43 |
| ▸ | PSMB3 | P49720 | 4/20 | 0.43 |
| ▸ | PSMB2 | P49721 | 4/20 | 0.43 |
| ▸ | PSMA6 | P60900 | 4/20 | 0.43 |
| ▸ | PSMA8 | Q8TAA3 | 4/20 | 0.43 |
| ▸ | PSMB7 | Q99436 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244199 | 0.91 | MEN1 (0.49) | SLC6A9ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL3239983 | 0.88 | UTS2R (0.42) | GPR139SLC6A9ALDH1A1MEN1KMT2A | |
| SCHEMBL3245066 | 0.87 | P2RX7 (0.43) | SLC6A9ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3240099 | 0.86 | CRHR1 (0.46) | SLC6A9ALDH1A1MEN1KMT2A | |
| SCHEMBL3239515 | 0.86 | KCNA3 (0.44) | GPR139SLC6A9MEN1KMT2ACYP3A4 | |
| SCHEMBL3238239 | 0.85 | CHRM1 (0.42) | GPR139SLC6A9MEN1KMT2ACYP3A4 | |
| SCHEMBL3237145 | 0.85 | AVPR2 (0.43) | SLC6A9ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4359374 | 0.84 | SLC6A9 (0.41) | SLC6A9MEN1KMT2A | |
| SCHEMBL3238379 | 0.84 | ACLY (0.45) | SLC6A9ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3240657 | 0.84 | TACR3 (0.43) | SLC6A9CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745642-B2 | Glycine transport inhibitors | GLAXO GROUP LIMITED (GB) | 2010-06-29 | — | — | US | disclosed |
| US-7745642-B2 | Glycine transport inhibitors | GLAXO GROUP LIMITED (GB) | 2010-06-29 | — | — | US | disclosed |
| US-7745642-B2 | Glycine transport inhibitors | GLAXO GROUP LIMITED (GB) | 2010-06-29 | — | — | US | disclosed |
| US-20080287547-A1 | Glycine Transport Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| US-20080287547-A1 | Glycine Transport Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| US-20080287547-A1 | Glycine Transport Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| WO-2006067423-A1 | GLYCINE TRANSPORT INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287547-A1 | Glycine Transport Inhibitors | SLC18A2, SLC6A5, SLC1A2 | GPR139 932/4885PSMB5 2619/4885PSMB11 3353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.