Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240810 | 0.87 | ACMSD (0.39) | HDAC1HDAC3LTB4RHDAC2HDAC6 | |
| SCHEMBL28253512 | 0.79 | TBXAS1 (0.47) | HDAC1TBXAS1HDAC3HDAC2HDAC6 | |
| SCHEMBL20591107 | 0.72 | TBXAS1 (0.45) | HDAC1TBXAS1HDAC3HDAC2HDAC6 | |
| SCHEMBL3236466 | 0.71 | HDAC1 (0.41) | HDAC1HDAC3LTB4RHDAC2HDAC6 | |
| SCHEMBL1769746 | 0.69 | NPSR1 (0.53) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL10596450 | 0.69 | NPSR1 (0.53) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL3236989 | 0.69 | HDAC1 (0.38) | HDAC1HDAC3LTB4RHDAC2HDAC6 | |
| SCHEMBL4138868 | 0.68 | NPSR1 (0.55) | — | |
| SCHEMBL3242812 | 0.67 | ALDH1A1 (0.40) | HDAC1HDAC3HDAC2HDAC6HDAC4 | |
| SCHEMBL16369620 | 0.67 | ALDH1A1 (0.40) | HDAC1HDAC3HDAC2HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |