Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | ADH1A | P07327 | 2/20 | 0.41 |
| ▸ | ADH1C | P00326 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5430139 | 0.98 | LMNA (0.43) | LMNAKMT2AMEN1ADH1AADH1C | |
| SCHEMBL2096556 | 0.80 | KMT2A (0.42) | LMNAKMT2AMEN1ADH1AADH1C | |
| SCHEMBL2096559 | 0.80 | KMT2A (0.42) | LMNAKMT2AMEN1ADH1AADH1C | |
| SCHEMBL27206868 | 0.78 | HTR2A (0.46) | LMNAKMT2AMEN1ADH1AADH1C | |
| SCHEMBL2090738 | 0.77 | KMT2A (0.44) | LMNAKMT2AMEN1ADH1AADH1C | |
| SCHEMBL2090736 | 0.77 | KMT2A (0.44) | LMNAKMT2AMEN1ADH1AADH1C | |
| SCHEMBL13622809 | 0.77 | KMT2A (0.44) | LMNAKMT2AMEN1ADH1AADH1C | |
| SCHEMBL3149066 | 0.76 | HTR2A (0.47) | LMNAKMT2AMEN1ADH1AADH1C | |
| SCHEMBL7665233 | 0.76 | ALDH1A1 (0.44) | LMNAKMT2AMEN1ADH1AADH1C | |
| SCHEMBL8171738 | 0.76 | KMT2A (0.42) | LMNAKMT2AMEN1ADH1AADH1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586577-B2 | Diazepane acetamide derivatives as selective 11B-HSD1 inhibitors | MERCK PATENT GMBH (DE) | 2013-11-19 | — | — | US | disclosed |
| US-20120283247-A1 | DIAZEPANE ACETAMIDE DERIVATIVES AS SELECTIVE 11B-HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2012-11-08 | — | — | US | disclosed |
| US-8242107-B2 | Diazepane-acetamide derivatives as selective 11β-HSD1 inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-08-14 | — | — | US | disclosed |
| EP-2078001-B1 | DIAZEPANE-ACETAMIDE DERIVATIVES AS SELECTIVE 11 -HSD1 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-05-12 | — | — | EP | disclosed |
| US-20100069365-A1 | Diazepane-acetamide derivatives as selective 11B-HSD1 inhibitors | MERCK PATENT GMBH (DE) | 2010-03-18 | — | — | US | disclosed |
| EP-1918285-A1 | Diazepane-acetamide derivatives as selective 11beta-HSD1 inhibitors | Merck Sante (FR) | 2008-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069365-A1 | Diazepane-acetamide derivatives as selective 11B-HSD1 inhibitors | HSD11B1, HSD11B2, HSD17B1 | LMNA 3140/4885KMT2A 1319/4885MEN1 1303/4885 |
| US-20120283247-A1 | DIAZEPANE ACETAMIDE DERIVATIVES AS SELECTIVE 11B-HSD1 INHIBITORS | HSD11B1, HSD11B2, HSD17B1 | LMNA 3332/4885KMT2A 1357/4885MEN1 1368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.