Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711414 | 0.85 | L3MBTL1 (0.50) | ALDH1A1L3MBTL1 | |
| SCHEMBL1913624 | 0.76 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AALOX5 | |
| SCHEMBL15319101 | 0.75 | MEN1 (0.39) | ALDH1A1L3MBTL1MEN1KMT2AALOX5 | |
| SCHEMBL3209123 | 0.74 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1MEN1KMT2ATSHR | |
| SCHEMBL4973395 | 0.73 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1MEN1KMT2ATSHR | |
| SCHEMBL28343493 | 0.73 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1MEN1KMT2ATSHR | |
| SCHEMBL15319103 | 0.72 | ALOX5 (0.41) | ALDH1A1L3MBTL1MEN1KMT2AHPGD | |
| SCHEMBL8900203 | 0.72 | ALOX5 (0.45) | ALDH1A1L3MBTL1MEN1KMT2AHPGD | |
| SCHEMBL19633464 | 0.72 | RCE1 (0.50) | ALDH1A1MEN1KMT2ATSHRHPGD | |
| SCHEMBL16631727 | 0.72 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262802-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | Novartis AG (CH) | 2010-12-22 | — | — | EP | disclosed |
| WO-2010026124-A1 | PICOLINAMIDE DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |
| WO-2009109576-A1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2009-09-11 | — | — | WO | disclosed |