Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15319114 | 0.84 | L3MBTL1 (0.46) | ALOX5LTA4HL3MBTL1 | |
| SCHEMBL15319115 | 0.84 | L3MBTL1 (0.46) | ALOX5LTA4HL3MBTL1 | |
| SCHEMBL1913624 | 0.84 | ALDH1A1 (0.42) | ALOX5ALDH1A1MEN1KMT2A | |
| SCHEMBL3209123 | 0.76 | ALDH1A1 (0.43) | ALOX5HPGDALDH1A1PTGS1PTGS2 | |
| SCHEMBL4973395 | 0.75 | ALDH1A1 (0.42) | ALOX5HPGDALDH1A1PTGS1PTGS2 | |
| SCHEMBL28343493 | 0.75 | ALDH1A1 (0.46) | ALOX5ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8900203 | 0.74 | ALOX5 (0.45) | ALOX5HPGDALDH1A1PTGS1PTGS2 | |
| SCHEMBL3241202 | 0.72 | ALDH1A1 (0.41) | ALOX5HPGDALDH1A1PTGS1PTGS2 | |
| SCHEMBL15318910 | 0.72 | L3MBTL1 (0.47) | LTA4HL3MBTL1 | |
| SCHEMBL15318912 | 0.72 | L3MBTL1 (0.47) | LTA4HL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834239-A1 | HETEROBICYCLIC COMPOUNDS AS BETA-LACTAMASE INHIBITORS | Astrazeneca AB (SE) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013150296-A1 | HETEROBICYCLIC COMPOUNDS AS BETA-LACTAMASE INHIBITORS | ASTRAZENECA AB (SE) | 2013-10-10 | — | — | WO | disclosed |