Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.54 |
| ▸ | TSHR | P16473 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 7/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817207 | 0.85 | HSD17B10 (0.65) | KDM4EHSD17B10ALDH1A1TSHRHPGD | |
| SCHEMBL7012598 | 0.80 | GPR174 (0.59) | KDM4EHSD17B10ALDH1A1GAAL3MBTL1 | |
| SCHEMBL15435872 | 0.77 | GPR174 (0.62) | KDM4EHSD17B10TSHRGAAMAPT | |
| SCHEMBL7010637 | 0.76 | FFAR3 (0.54) | KDM4EHSD17B10ALDH1A1HPGDGAA | |
| SCHEMBL2998592 | 0.71 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1TSHRHPGD | |
| SCHEMBL3326098 | 0.69 | KDM4E (0.80) | KDM4EHSD17B10ALDH1A1TSHRHPGD | |
| SCHEMBL3242208 | 0.69 | FFAR3 (0.70) | KDM4EHSD17B10ALDH1A1TSHRHPGD | |
| SCHEMBL3324020 | 0.69 | KDM4E (0.78) | KDM4EHSD17B10ALDH1A1TSHRHPGD | |
| SCHEMBL16583705 | 0.69 | HSD17B10 (0.67) | KDM4EHSD17B10ALDH1A1TSHRHPGD | |
| SCHEMBL17792787 | 0.68 | SHMT2 (1.00) | KDM4EHSD17B10ALDH1A1TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1103554-B9 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-12-17 | — | — | EP | claimed |
| EP-1103554-B1 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-03-12 | — | — | EP | claimed |
| EP-1103554-B9 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-12-17 | — | — | EP | disclosed |
| EP-1103554-B1 | Derivatives of dihydrofuro-(3,4-b)-quinolein-1-ones, process of préparation and phamaceutical compositions containing them | SERVIER LAB (FR) | 2003-03-12 | — | — | EP | disclosed |