Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10994146 | 0.80 | HTT (0.49) | TP53LMNANPC1RAB9ACASP3 | |
| SCHEMBL2939270 | 0.80 | NPC1 (0.75) | TP53LMNANPC1RAB9ACASP3 | |
| SCHEMBL544007 | 0.73 | HTT (0.69) | TP53LMNANPC1RAB9ACASP3 | |
| SCHEMBL10990606 | 0.72 | CYP2C9 (0.44) | NPC1RAB9ASMN1; SMN2ALOX15TSHR | |
| SCHEMBL10988729 | 0.72 | PAX8 (0.37) | TP53LMNAALOX15TSHRWNT3A | |
| SCHEMBL15280046 | 0.72 | NPC1 (0.49) | TP53LMNANPC1RAB9ACASP3 | |
| SCHEMBL5542855 | 0.71 | CYP2C9 (0.43) | NPC1RAB9ASMN1; SMN2ALOX15TSHR | |
| SCHEMBL26538335 | 0.71 | CYP2C9 (0.46) | LMNAALOX15TSHRALDH1A1CYP2C9 | |
| SCHEMBL3357170 | 0.71 | HSD17B1 (0.47) | TP53LMNANPC1RAB9ACASP3 | |
| SCHEMBL3249923 | 0.70 | GBA1 (0.36) | RAB9ASMN1; SMN2ALOX15CYP2C9MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001220-A1 | NEW 1,2,4-TRIAZINE DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF | MUTABILIS SA (FR) | 2010-01-07 | — | — | WO | disclosed |
| EP-2141164-A1 | New 1,2,4-triazine derivatives and biological applications thereof | Mutabilis (FR) | 2010-01-06 | — | — | EP | disclosed |