Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 4/20 | 0.39 |
| ▸ | IGF1R | P08069 | 4/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247173 | 0.88 | ACHE (0.36) | IGF1RACHEMEN1KMT2AMAOB | |
| SCHEMBL3242252 | 0.74 | LTA4H (0.42) | ACHEMEN1ALDH1A1KMT2A | |
| SCHEMBL4797887 | 0.71 | IGF1R (0.43) | P2RX3IGF1RKLKB1NPC1RAB9A | |
| SCHEMBL2330756 | 0.71 | TEAD4 (0.47) | P2RX3IGF1RKLKB1NPC1RAB9A | |
| SCHEMBL12677967 | 0.71 | HTT (0.50) | IGF1RNPC1RAB9ASMN1; SMN2SRC | |
| SCHEMBL3237678 | 0.71 | P2RX3 (0.34) | P2RX3IGF1RKLKB1ACHEMAOB | |
| SCHEMBL17274321 | 0.70 | MIF (0.51) | P2RX3IGF1RKLKB1NPC1RAB9A | |
| SCHEMBL2463239 | 0.70 | IGF1R (0.40) | IGF1RSRCMEN1ALDH1A1HPGD | |
| SCHEMBL3235955 | 0.70 | PYCR1 (0.41) | SMN1; SMN2PYCR1ALDH1A1HTTKMT2A | |
| SCHEMBL12245330 | 0.69 | RAB9A (0.50) | P2RX3IGF1RNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | P2RX3 229/4885IGF1R 1166/4885DHFR 736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.