Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 4/20 | 0.51 |
| ▸ | ABL1 | P00519 | 5/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247802 | 0.87 | BRAF (0.58) | NPC1RAB9ASMN1; SMN2FYNTP53 | |
| SCHEMBL3247981 | 0.85 | PTGS1 (0.61) | RAB9ABRAFABL1BCRTSHR | |
| SCHEMBL3244240 | 0.83 | BRAF (0.69) | FYNBRAFABL1BCR | |
| SCHEMBL3241930 | 0.82 | FYN (0.51) | FYNBRAF | |
| SCHEMBL3247870 | 0.80 | TSHR (0.67) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL14200588 | 0.80 | ALDH1A1 (0.62) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL3242880 | 0.80 | BRAF (0.54) | NPC1RAB9ASMN1; SMN2FYNBRAF | |
| SCHEMBL3247799 | 0.79 | ABL1 (0.60) | BRAFABL1BCR | |
| SCHEMBL3244837 | 0.79 | FYN (0.57) | FYNBRAF | |
| SCHEMBL3242121 | 0.78 | BRAF (0.53) | NPC1RAB9ASMN1; SMN2FYNBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |