Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.53 |
| ▸ | SYK | P43405 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 4/20 | 0.45 |
| ▸ | WNT3A | P56704 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247802 | 0.86 | BRAF (0.58) | BRAFSYKEGFRKDRFYN | |
| SCHEMBL3234838 | 0.85 | BRAF (0.54) | BRAFFYNNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3244240 | 0.84 | BRAF (0.69) | BRAFFYNMAPTKDM4EMAPK1 | |
| SCHEMBL3242870 | 0.80 | BRAF (0.62) | BRAFFGFR1FYNNPC1RAB9A | |
| SCHEMBL3242880 | 0.78 | BRAF (0.54) | BRAFSYKEGFRKDRFYN | |
| SCHEMBL3246389 | 0.78 | CTSC (0.58) | BRAFSYKEGFRKDRFYN | |
| SCHEMBL3242919 | 0.78 | BRAF (0.47) | BRAFSYKEGFRFYN | |
| SCHEMBL3249357 | 0.77 | NPC1 (0.59) | BRAFFYNNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1933785 | 0.77 | TTK (0.68) | SYK | |
| SCHEMBL3244032 | 0.76 | KDR (0.48) | BRAFKDRFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |