Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254793 | 0.92 | HRH2 (0.40) | CHEK1WEE1NPC1CSF1RKIT | |
| SCHEMBL3252380 | 0.88 | CSF1R (0.43) | CHEK1WEE1NPC1CSF1RSCN9A | |
| SCHEMBL3253850 | 0.87 | SCN9A (0.38) | CHEK1WEE1NPC1CSF1RSCN9A | |
| SCHEMBL3249865 | 0.87 | KDM4E (0.40) | CHEK1WEE1NPC1SCN9AALDH1A1 | |
| SCHEMBL3243041 | 0.85 | WEE1 (0.38) | WEE1NPC1CSF1RSCN9AALDH1A1 | |
| SCHEMBL3249012 | 0.85 | NPC1 (0.46) | NPC1CSF1RKITFLT3ALDH1A1 | |
| SCHEMBL3244745 | 0.84 | GABRA1 (0.36) | CSF1RALDH1A1HPGDMEN1TP53 | |
| SCHEMBL3244562 | 0.84 | CCNC (0.38) | NPC1ALDH1A1HPGDMEN1TP53 | |
| SCHEMBL3252050 | 0.84 | GAA (0.40) | CHEK1WEE1NPC1CSF1RALDH1A1 | |
| SCHEMBL3249476 | 0.83 | ICMT (0.37) | CHEK1WEE1NPC1CSF1RSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |