Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLCN2 | P51788 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27229008 | 0.84 | ALDH1A1 (0.44) | CLCN2ALDH1A1HMGB1ALOX15FOLH1 | |
| SCHEMBL21616779 | 0.83 | BID (0.55) | ALOX15KDM4EHSD17B10 | |
| SCHEMBL27571198 | 0.82 | HMGB1 (0.51) | CLCN2ALDH1A1HMGB1ALOX15FOLH1 | |
| SCHEMBL4368624 | 0.82 | HMGB1 (0.43) | CLCN2ALDH1A1HMGB1ALOX15FOLH1 | |
| SCHEMBL19834696 | 0.82 | AKR1C3 (0.48) | CLCN2ALDH1A1HPGDTDP1 | |
| Acetic Acid SCHEMBL29701125 | 0.81 | GABRA1 (0.50) | CLCN2GABRA1GABRB2ALOX15TDP1 | |
| SCHEMBL11322881 | 0.81 | TSHR (0.59) | ALDH1A1ALOX15FOLH1TSHR | |
| SCHEMBL2443197 | 0.80 | ALDH1A1 (0.60) | ALDH1A1HMGB1ALOX15KDM4EHPGD | |
| SCHEMBL4238088 | 0.80 | KAT6A (0.54) | CLCN2GABRA1GABRB2ALDH1A1HMGB1 | |
| SCHEMBL578127 | 0.79 | CLCN2 (0.56) | CLCN2GABRA1GABRB2ALDH1A1HMGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4284619-A | INJECTING RADIOIODINE COMPOUND | MEDI-PHYSICS, INC. (US) | 1981-08-18 | — | — | US | claimed |
| CN-111433577-A | Temperature detection label and article management device using same | 株式会社日立制作所 | 2020-07-17 | — | — | CN | disclosed |
| US-9638690-B2 | Compounds and compositions for use as alkylating agent sensors and methods of use thereof | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2017-05-02 | — | — | US | disclosed |
| US-20160131641-A1 | COMPOUNDS AND COMPOSITIONS FOR USE AS ALKYLATING AGENT SENSORS AND METHODS OF USE THEREOF | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2016-05-12 | — | — | US | disclosed |
| EP-1799627-B1 | IRON OR COBALT-CATALYZED CARBON-CARBON COUPLING REACTION OF ARYLS, ALKENES AND ALKINES WITH COPPER REAGENTS | SALTIGO GMBH (DE) | 2010-05-05 | — | — | EP | disclosed |
| US-7468378-B2 | Substituted quinoline compounds | PFIZER INC. (US) | 2008-12-23 | — | — | US | disclosed |
| US-7393958-B2 | Triamide-substituted heterobicyclic compounds | PFIZER, INC. (US) | 2008-07-01 | — | — | US | disclosed |
| US-7368573-B2 | Triamide-substituted heterobicyclic compounds | PFIZER INC. (US) | 2008-05-06 | — | — | US | disclosed |
| EP-1799627-A1 | IRON OR COBALT-CATALYZED CARBON-CARBON COUPLING REACTION OF ARYLS, ALKENES AND ALKINES WITH COPPER REAGENTS | Ludwig-Maximilians-Universität München (DE) | 2007-06-27 | — | — | EP | disclosed |
| US-20070093525-A1 | Triamide-substituted heterobicyclic compounds | PFIZER INC | 2007-04-26 | — | — | US | disclosed |
| EP-0977734-A2 | ARYLSECOCHOLADIENE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998047866-A2 | ARYLSECOCHOLADIENE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-29 | — | — | WO | disclosed |
| WO-1995003700-A1 | BRIDGED BIPHENYL CARBAPENEM ANTIBACTERIAL COMPOUNDS | MERCK & CO., INC. (US) | 1995-02-09 | — | — | WO | disclosed |
| WO-1995003699-A1 | BRIDGED BIPHENYL CARBAPENEM COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1995-02-09 | — | — | WO | disclosed |
| US-5374630-A | Bridged carbapenem antibacterial compounds | MERCK & CO., INC. (US) | 1994-12-20 | — | — | US | disclosed |
| US-5372993-A | Bridged carbapenem compounds, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 1994-12-13 | — | — | US | disclosed |
| EP-0181526-B1 | BENZOIC ACID DERIVATIVES | Chugai Seiyaku Kabushiki Kaisha (JP) | 1989-01-18 | — | — | EP | disclosed |
| US-4698364-A | INFECTION CONTROL | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1987-10-06 | — | — | US | disclosed |
| EP-0181526-A1 | Benzoic acid derivatives | Chugai Seiyaku Kabushiki Kaisha (JP) | 1986-05-21 | — | — | EP | disclosed |
| US-4020169-A | FROM ARYL IODIDE OR BROMIDE AND TRIFLUOROMETHYL THIO COPPER | MERCK & CO., INC. (US) | 1977-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160131641-A1 | COMPOUNDS AND COMPOSITIONS FOR USE AS ALKYLATING AGENT SENSORS AND METHODS OF USE THEREOF | MGMT, MCL1, OGG1 | CLCN2 1424/4885GABRA1 3516/4885GABRB2 4313/4885 |
| US-20070093525-A1 | Triamide-substituted heterobicyclic compounds | APOB, MTPN, CTRB1 | CLCN2 3889/4885GABRA1 2842/4885GABRB2 1237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.