Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.40 |
| ▸ | KDM4B | O94953 | 2/20 | 0.40 |
| ▸ | KDM5C | P41229 | 2/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6512842 | 0.80 | RAB9A (0.47) | CHEK2PARP1KDM4AKDM4BKDM5C | |
| SCHEMBL496710 | 0.78 | LTA4H (0.47) | CHEK2PARP1KDM4AKDM4BKDM5C | |
| SCHEMBL14754324 | 0.78 | RAB9A (0.47) | CHEK2PARP1METAP1METAP2KDM4E | |
| SCHEMBL679357 | 0.78 | METAP2 (0.46) | METAP1METAP2KDM4ENPC1TP53 | |
| SCHEMBL18725070 | 0.78 | TSHR (0.39) | CHEK2PARP1KDM4AKDM4BKDM5C | |
| SCHEMBL31126424 | 0.78 | METAP2 (0.39) | CHEK2PARP1KDM4AKDM4BKDM5C | |
| SCHEMBL10284703 | 0.78 | KMT2A (0.48) | CHEK2PARP1METAP1TSHRMETAP2 | |
| SCHEMBL534208 | 0.78 | ESR1 (0.42) | CHEK2PARP1KDM4AKDM4BKDM5C | |
| SCHEMBL679707 | 0.77 | SCN9A (0.47) | PARP1KDM4AKDM4BKDM5CKDM5B | |
| SCHEMBL9231483 | 0.77 | METAP1 (0.46) | CHEK2PARP1KDM4AKDM4BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411935-B1 | USE OF 4- (4-THIAZOLYL)PHENOXL ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARM CO LTD (KR) | 2010-05-19 | — | — | EP | disclosed |