Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | NPC1 | O15118 | 9/20 | 0.57 |
| ▸ | RAB9A | P51151 | 9/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KHK | P50053 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5405724 | 0.98 | KMT2A (0.64) | KMT2ANPC1RAB9AHTTKDM4E | |
| SCHEMBL17619445 | 0.86 | KMT2A (0.57) | KMT2ANPC1RAB9AHTTKDM4E | |
| SCHEMBL2989287 | 0.80 | NPBWR1 (0.49) | KMT2ANPC1RAB9AHTTNPSR1 | |
| SCHEMBL6205563 | 0.80 | KMT2A (1.00) | KMT2ANPC1RAB9AHTTKDM4E | |
| SCHEMBL10768961 | 0.79 | KMT2A (0.54) | KMT2ANPC1RAB9AHTTKDM4E | |
| SCHEMBL18445806 | 0.79 | RAB9A (0.74) | KMT2ANPC1RAB9AHTTKDM4E | |
| SCHEMBL10672542 | 0.79 | RAB9A (0.58) | KMT2ANPC1RAB9AHTTKDM4E | |
| SCHEMBL3427893 | 0.79 | RIPK2 (0.68) | KMT2ANPC1RAB9AHTTKDM4E | |
| SCHEMBL17365303 | 0.79 | KMT2A (0.57) | KMT2ANPC1RAB9AHTTKDM4E | |
| SCHEMBL3251404 | 0.78 | RAB9A (0.56) | KMT2ANPC1RAB9AHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1685091-B1 | M-DIAMINOBENZOLES AND THE ACIDIC ADDUCTS THEREOF AND USE THEREOF IN COLOURING AGENTS | PROCTER & GAMBLE (US) | 2010-05-19 | — | — | EP | disclosed |
| EP-1718601-B1 | (3,5-DIAMINOPHENYL)(2,4-DIHYDROXYPHENYL)METHANONE AND ITS ACID ADDUCTS, METHOD FOR THE PRODUCTION OF THE LATTER AND USE OF SAID COMPOUNDS FOR COLOURING FIBRES | WELLA AG (DE) | 2009-03-25 | — | — | EP | disclosed |
| US-7455697-B2 | (3,5-diaminophenyl)(2,4-dihydroxyphenyl)methanone and the acid adducts thereof, method for their preparation and use of these compounds for dyeing fibers | WELLA AG (DE) | 2008-11-25 | — | — | US | disclosed |
| US-7361198-B2 | M-diaminobenzenes, their acid adducts and the use thereof in colorants | WELLA AG (DE) | 2008-04-22 | — | — | US | disclosed |
| US-20070180629-A1 | (3,5-Diaminophenyl)(2,4-dihydroxyphenyl)methanone and the acid adducts thereof, method for their preparation and use of these compounds for dyeing fibers | Wella GmbH (DE) | 2007-08-09 | — | — | US | disclosed |
| US-7195649-B2 | N-aryl-4,5-diaminopyrazoles and dyes containing said compounds | WELLA AG (DE) | 2007-03-27 | — | — | US | disclosed |
| US-7195649-B2 | N-aryl-4,5-diaminopyrazoles and dyes containing said compounds | WELLA AG (DE) | 2007-03-27 | — | — | US | disclosed |
| EP-1718601-A1 | (3,5-DIAMINOPHENYL)(2,4-DIHYDROXYPHENYL)METHANONE AND ITS ACID ADDUCTS, METHOD FOR THE PRODUCTION OF THE LATTER AND USE OF SAID COMPOUNDS FOR COLOURING FIBRES | Wella Aktiengesellschaft (DE) | 2006-11-08 | — | — | EP | disclosed |
| EP-1636219-B1 | NOVEL THIAZOLYLMETHYL PYRAZOLES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF IN DYES FOR KERATIN FIBERS | WELLA AG (DE) | 2006-11-02 | — | — | EP | disclosed |
| US-20060183781-A1 | Novel thiazolylmethyl pyrazoles, method for the production thereof, and use thereof in dyes for keratin fibers | WELLA AG (DE) | 2006-08-17 | — | — | US | disclosed |
| EP-1685091-A1 | M-DIAMINOBENZOLES AND THE ACIDIC ADDUCTS THEREOF AND USE THEREOF IN COLOURING AGENTS | Wella Aktiengesellschaft (DE) | 2006-08-02 | — | — | EP | disclosed |
| EP-1636219-A1 | NOVEL THIAZOLYLMETHYL PYRAZOLES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF IN DYES FOR KERATIN FIBERS | Wella Aktiengesellschaft (DE) | 2006-03-22 | — | — | EP | disclosed |
| US-20060047172-A1 | M-diaminobenzenes, their acid adducts and the use thereof in colorants | Wella GmbH (DE) | 2006-03-02 | — | — | US | disclosed |
| WO-2005080315-A1 | (3,5-DIAMINOPHENYL)(2,4-DIHYDROXYPHENYL)METHANONE AND ITS ACID ADDUCTS, METHOD FOR THE PRODUCTION OF THE LATTER AND USE OF SAID COMPOUNDS FOR COLOURING FIBRES | WELLA AKTIENGESELLSCHAFT (DE) | 2005-09-01 | — | — | WO | disclosed |
| WO-2005051889-A1 | M-DIAMINOBENZOLES AND THE ACIDIC ADDUCTS THEREOF AND USE THEREOF IN COLOURING AGENTS | WELLA AKTIENGESELLSCHAFT (DE) | 2005-06-09 | — | — | WO | disclosed |
| WO-2004106332-A1 | NOVEL THIAZOLYLMETHYL PYRAZOLES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF IN DYES FOR KERATIN FIBERS | WELLA AKTIENGESELLSCHAFT (DE) | 2004-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060047172-A1 | M-diaminobenzenes, their acid adducts and the use thereof in colorants | DDT, NQO1, MDH2 | KMT2A 807/4885NPC1 4726/4885RAB9A 3667/4885 |
| US-20060183781-A1 | Novel thiazolylmethyl pyrazoles, method for the production thereof, and use thereof in dyes for keratin fibers | KRT18, CBR3, CDC73 | KMT2A 3398/4885NPC1 4338/4885RAB9A 4334/4885 |
| US-20070180629-A1 | (3,5-Diaminophenyl)(2,4-dihydroxyphenyl)methanone and the acid adducts thereof, method for their preparation and use of these compounds for dyeing fibers | GRHPR, MB, COX5B | KMT2A 1236/4885NPC1 4038/4885RAB9A 4629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.