Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147192 | 0.88 | KCNH2 (0.54) | MAPTALDH1A1HTTCLK1NPSR1 | |
| SCHEMBL3244126 | 0.87 | KCNH2 (0.49) | MAPTALDH1A1HTTCLK1NPSR1 | |
| SCHEMBL3256183 | 0.80 | MAOA (0.46) | ALDH1A1KCNH2PDGFRALMNAKIT | |
| SCHEMBL1147533 | 0.77 | KCNH2 (0.60) | MAPTALDH1A1HTTCLK1NPSR1 | |
| SCHEMBL3126601 | 0.76 | KCNH2 (0.67) | KCNH2 | |
| SCHEMBL3256178 | 0.75 | SMN1; SMN2 (0.49) | MAPTALDH1A1HTTNPSR1SMN1; SMN2 | |
| SCHEMBL3251044 | 0.75 | MTNR1B (0.53) | ALDH1A1NPSR1MEN1KMT2AMAPK1 | |
| SCHEMBL3251040 | 0.75 | MTNR1B (0.53) | ALDH1A1NPSR1MEN1KMT2AMAPK1 | |
| SCHEMBL3249031 | 0.74 | ALDH1A1 (0.44) | MAPTALDH1A1HTTNPSR1SMN1; SMN2 | |
| SCHEMBL3254277 | 0.73 | KCNH2 (0.48) | MAPTALDH1A1HTTCLK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001478-B1 | CYCLOHEXYL OR PIPERIDINYL CARBOXAMIDE ANTIBIOTIC DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-06-02 | — | — | EP | claimed |