Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242734 | 0.88 | BRD4 (0.41) | KDM4ECA12CA9KMT2AMEN1 | |
| SCHEMBL3255461 | 0.88 | BRD4 (0.52) | KMT2AMEN1TSHRALDH1A1LMNA | |
| SCHEMBL3255334 | 0.87 | BRD4 (0.36) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL3251557 | 0.82 | BRD4 (0.55) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL3253196 | 0.82 | MMP2 (0.53) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL13928204 | 0.82 | MMP13 (0.51) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL3254789 | 0.82 | PKM (0.51) | KDM4EKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3249074 | 0.82 | GABRA1 (0.46) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL13928203 | 0.82 | BRD4 (0.53) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL3246250 | 0.82 | HIF1A (0.53) | CLEC4MJAK2JAK3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |