Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.35 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.35 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3255483 | 0.89 | BRD4 (0.50) | BRD4THRBPOLBMEN1KMT2A | |
| SCHEMBL3247548 | 0.87 | GABRA1 (0.41) | BRD4TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL3249789 | 0.84 | BRD4 (0.53) | BRD4THRBKDM4EPOLBMEN1 | |
| SCHEMBL3254540 | 0.84 | MMP2 (0.46) | BRD4KDM4EPOLBMEN1KMT2A | |
| SCHEMBL3253968 | 0.83 | PKM (0.49) | THRBKDM4EPOLBLMNAMEN1 | |
| SCHEMBL3243057 | 0.83 | CHEK1 (0.37) | BRD4KDM4EPOLBLMNAMEN1 | |
| SCHEMBL3249852 | 0.83 | BRD4 (0.52) | BRD4MEN1KMT2ATP53MAPT | |
| SCHEMBL3264336 | 0.83 | HIF1A (0.47) | BRD4THRBPOLBLMNAMEN1 | |
| SCHEMBL3249374 | 0.82 | CHEK1 (0.47) | BRD4KDM4ELMNAMEN1KMT2A | |
| SCHEMBL3255978 | 0.82 | FEN1 (0.39) | CSF1RLIMK1LIMK2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |