Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL325375 | 0.87 | SLC6A2 (0.45) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL12503222 | 0.85 | CYP2D6 (0.47) | ALDH1A1MEN1KMT2ASMN1; SMN2SLC6A3 | |
| SCHEMBL324172 | 0.72 | CYP2D6 (0.67) | MEN1KMT2ASLC6A3SLC6A2SLC6A4 | |
| SCHEMBL323778 | 0.71 | CHRM2 (0.58) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL325002 | 0.71 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ASMN1; SMN2SLC6A3 | |
| SCHEMBL327686 | 0.69 | CYP2D6 (0.43) | ALDH1A1MEN1KMT2ASMN1; SMN2SLC6A3 | |
| SCHEMBL29585835 | 0.68 | SLC6A3 (0.56) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL29585404 | 0.68 | SLC6A3 (0.56) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL22206745 | 0.68 | SLC6A3 (0.56) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| SCHEMBL22206766 | 0.68 | SLC6A3 (0.56) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590953-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2013-05-15 | — | — | EP | claimed |
| WO-2012004604-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2012-01-12 | — | — | WO | claimed |
| EP-2590953-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004604-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2012-01-12 | — | — | WO | disclosed |