Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.51 |
| ▸ | CACNB4 | O00305 | 5/20 | 0.45 |
| ▸ | CACNA1A | O00555 | 5/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.45 |
| ▸ | CACNG3 | O60359 | 5/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 5/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.45 |
| ▸ | CACNB3 | P54284 | 5/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.45 |
| ▸ | CACNG7 | P62955 | 5/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 5/20 | 0.45 |
| ▸ | CACNG1 | Q06432 | 5/20 | 0.45 |
| ▸ | CACNB2 | Q08289 | 5/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.45 |
| ▸ | CACNA1E | Q15878 | 5/20 | 0.45 |
| ▸ | CACNA2D4 | Q7Z3S7 | 5/20 | 0.45 |
| ▸ | CACNA2D3 | Q8IZS8 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431649 | 0.99 | HTR6 (0.52) | HTR6CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL3257361 | 0.90 | HTR6 (0.65) | HTR6ALDH1A1L3MBTL1HTTNCOA1 | |
| SCHEMBL3251276 | 0.87 | HTR6 (0.66) | HTR6ALDH1A1TSHRRECQLL3MBTL1 | |
| SCHEMBL4553448 | 0.82 | HTR6 (0.42) | HTR6CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL3255751 | 0.81 | HTR6 (0.43) | HTR6CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL3256687 | 0.80 | HTR6 (0.44) | HTR6CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL3264614 | 0.78 | HTR6 (0.54) | HTR6CYP19A1 | |
| SCHEMBL3252401 | 0.76 | HTR6 (0.44) | HTR6TSHRCYP19A1CYP2D6CYP2C19 | |
| SCHEMBL19396331 | 0.76 | HTR6 (0.57) | HTR6CACNB4CACNA1ACACNA1GCACNG3 | |
| SCHEMBL5233760 | 0.75 | HTR6 (0.85) | HTR6CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537113-B9 | ARYLALKYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY USEFUL AS THERAPEUTIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LTD (IN) | 2010-05-26 | — | — | EP | disclosed |
| EP-1537113-B1 | ARYLALKYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY USEFUL AS THERAPEUTIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SUVEN LIFE SCIENCES LTD (IN) | 2009-10-07 | — | — | EP | disclosed |
| US-7297711-B2 | Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them | SUVEN LIFE SCIENCES LIMITED (IN) | 2007-11-20 | — | — | US | disclosed |
| US-20050203103-A1 | Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them | SUVEN LIFE SCIENCES LIMITED (IN) | 2005-09-15 | — | — | US | disclosed |
| CN-1662538-A | Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them | SUVEN PHARMACEUTICALS LTD (IN) | 2005-08-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203103-A1 | Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them | TPH1, HTR1A, HTR7 | HTR6 9/4885CACNB4 2444/4885CACNA1A 1821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.