Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | ARG2 | P78540 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12883053 | 0.82 | CYP2D6 (0.47) | NPSR1SMN1; SMN2ALDH1A1PKMKMT2A | |
| SCHEMBL12000726 | 0.78 | — | — | |
| SCHEMBL20438382 | 0.78 | ALOX15 (0.38) | SMN1; SMN2TP53SIGMAR1PIK3CD | |
| SCHEMBL6057217 | 0.78 | ALOX15 (0.38) | SMN1; SMN2TP53SIGMAR1PIK3CD | |
| Ethane SCHEMBL3270216 | 0.76 | ALDH1A1 (0.50) | L3MBTL1POLBNPSR1ALDH1A1GAA | |
| SCHEMBL2721148 | 0.75 | ALDH1A1 (0.49) | L3MBTL1NPSR1ALDH1A1GAAKMT2A | |
| SCHEMBL5110597 | 0.74 | GLB1 (0.42) | — | |
| Propane SCHEMBL7890487 | 0.74 | ALDH1A1 (0.49) | L3MBTL1POLBALDH1A1GAAKMT2A | |
| SCHEMBL439524 | 0.73 | ALDH1A1 (0.46) | POLBSMN1; SMN2TP53SIGMAR1ALDH1A1 | |
| SCHEMBL13212100 | 0.73 | POLB (0.43) | POLBSMN1; SMN2ALDH1A1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233947-B2 | Sulfamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2016-01-12 | — | — | US | disclosed |
| US-20140243329-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-08-28 | — | — | US | disclosed |
| US-8748478-B2 | Sulfamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2014-06-10 | — | — | US | disclosed |
| CN-102325763-B | Sulfamides as TRPM8 modulators | JANSSEN PHARMACEUTICA NV | 2014-01-29 | — | — | CN | disclosed |
| EP-2379521-B1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-22 | — | — | EP | disclosed |
| US-20130237547-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2013-09-12 | — | — | US | disclosed |
| US-8436041-B2 | Sulfamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2013-05-07 | — | — | US | disclosed |
| CN-102325763-A | Sulfamides as TRPM8 modulators | JANSSEN PHARMACEUTICA NV | 2012-01-18 | — | — | CN | disclosed |
| WO-2010080397-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-07-15 | — | — | WO | disclosed |
| US-20100160337-A1 | SULFAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, NV (BE) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130237547-A1 | SULFAMIDES AS TRPM8 MODULATORS | TRPM8, TRPM5, TRPM2 | L3MBTL1 4055/4885POLB 4606/4885NPSR1 115/4885 |
| US-20100160337-A1 | SULFAMIDES AS TRPM8 MODULATORS | TRPM8, TRPM5, TRPM2 | L3MBTL1 4055/4885POLB 4606/4885NPSR1 115/4885 |
| US-20140243329-A1 | SULFAMIDES AS TRPM8 MODULATORS | TRPM8, TRPM5, TRPM2 | L3MBTL1 4055/4885POLB 4606/4885NPSR1 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.