Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 8/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.43 |
| ▸ | ITGA1 | P56199 | 2/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | CCR4 | P51679 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253952 | 0.92 | MEN1 (0.48) | HSD11B1SCN1ASCN5ASCN8APIK3CD | |
| SCHEMBL3255525 | 0.90 | SCN8A (0.44) | HSD11B1SCN1ASCN5ASCN8APIK3CA | |
| SCHEMBL3259074 | 0.87 | HTT (0.49) | HSD11B1SCN1ASCN5ASCN8APIK3CD | |
| SCHEMBL3256119 | 0.86 | SCN8A (0.40) | HSD11B1SCN1ASCN5ASCN8ACCR4 | |
| SCHEMBL3259023 | 0.85 | L3MBTL1 (0.41) | HSD11B1PPARGSCN1ASCN5ASCN8A | |
| SCHEMBL3259225 | 0.83 | TDP1 (0.45) | HSD11B1SCN1ASCN5ASCN8A | |
| SCHEMBL3256693 | 0.83 | ACLY (0.40) | SCN1ASCN5ASCN8ACCR4MEN1 | |
| SCHEMBL3256685 | 0.82 | SCN8A (0.37) | HSD11B1SCN1ASCN5ASCN8AITGAV | |
| SCHEMBL3257453 | 0.82 | SCN8A (0.40) | SCN1ASCN5ASCN8AMEN1KMT2A | |
| SCHEMBL3255776 | 0.82 | RAB9A (0.43) | SCN1ASCN5ASCN8APIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461325-B1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2010-05-26 | — | — | EP | claimed |