Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29957599 | 1.00 | TSHR (0.48) | TSHRMAPK1HTR3EHTR3BHTR3A | |
| SCHEMBL26667009 | 0.78 | TSHR (0.48) | TSHRMAPK1HTR3EHTR3BHTR3A | |
| SCHEMBL1754079 | 0.78 | HDAC8 (0.42) | ALDH1A1GAAMAPTTDP1CA1 | |
| Hydrochloric Acid SCHEMBL3983297 | 0.77 | TSHR (0.47) | TSHRMAPK1HTR3EHTR3BHTR3A | |
| SCHEMBL29951501 | 0.77 | CES2 (0.41) | TSHRMAPK1CES2ALDH1A1IDO1 | |
| SCHEMBL7529351 | 0.75 | DHFR (0.34) | — | |
| SCHEMBL62723 | 0.75 | TSHR (0.67) | TSHRMAPK1HTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL7124316 | 0.75 | TSHR (0.45) | TSHRMAPK1HTR3EHTR3BHTR3A | |
| SCHEMBL4156680 | 0.74 | TSHR (0.44) | TSHRMAPK1HTR3EHTR3BHTR3A | |
| Benzene SCHEMBL8568955 | 0.73 | TSHR (0.67) | TSHRMAPK1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2306788-A1 | Iridium compounds and devices made therewith | E. I. du Pont de Nemours and Company (US) | 2011-04-06 | — | — | EP | claimed |
| US-7129518-B2 | Electroluminescent iridium compounds with fluorinated phenylpryidines, phenylpyrimidines, and phenylquinolines and devices made with such compounds | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2006-10-31 | — | — | US | claimed |
| US-20040188673-A1 | Electroluminescent iridium compounds with fluorinated phenylpryidines, phenylpyrimidines, and phenylquinolines and devices made with such compounds | LG CHEM, LTD. (KR) | 2004-09-30 | — | — | US | claimed |
| US-20040108507-A1 | Electroluminescent iridium compounds with fluorinated phenylpryidines, phenylpyrimidines, and phenylquinolines and devices made with such compounds | LG CHEM, LTD. (KR) | 2004-06-10 | — | — | US | claimed |
| US-20040106007-A1 | Electroluminescent iridium compounds with fluorinated phenylpryidines, phenylpyrimidines, and phenylquinolines and devices made with such compounds | GRUSHIN VLADIMIR (US) | 2004-06-03 | — | — | US | claimed |
| US-20040094769-A1 | Electroluminescent iridium compounds with fluorinated phenylpyridines, phenylprimidines, and phenylquinolines and devices made with such compounds | LG CHEM, LTD. (KR) | 2004-05-20 | — | — | US | claimed |
| US-20040089867-A1 | Electroluminescent iridium compounds with fluorinated phenylpryidines, phenylpyrimidines, and phenylquinolines and devices made with such compounds | LG CHEM, LTD. (KR) | 2004-05-13 | — | — | US | claimed |
| WO-2003063555-A1 | ELECTROLUMINESCENT IRIDIUM COMPOUNDS WIHT FLUORINATED PHENYLPYRIDINES, PHENYLPYRIMIDINES, AND PHENYLQUINOLINES AND DEVICES MADE WITH SUCH COMPOUNDS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-07-31 | — | — | WO | claimed |
| US-20020190250-A1 | Electroluminescent iridium compounds with fluorinated phenylpyridines, phenylpyrimidines, and phenylquinolines and devices made with such compounds | LG CHEM, LTD. (KR) | 2002-12-19 | — | — | US | claimed |
| US-9750719-B2 | Tetrazole compounds as calcium channel blockers | Convergence Pharmaceuticals Limited (GB) | 2017-09-05 | — | — | US | disclosed |
| US-20160015687-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited (GB) | 2016-01-21 | — | — | US | disclosed |
| US-9115132-B2 | Tetrazole compounds as calcium channel blockers | Convergence Pharmaceuticals Limited (GB) | 2015-08-25 | — | — | US | disclosed |
| EP-2590953-B1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | CONVERGENCE PHARMACEUTICALS (GB) | 2014-10-29 | — | — | EP | disclosed |
| US-20130210796-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | Convergence Pharmaceuticals Limited | 2013-08-15 | — | — | US | disclosed |
| US-20010029298-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2001-10-11 | — | — | US | disclosed |
| US-6252079-B1 | CYCLIZATION OF CHEMICAL INTERMEDIATE; REACTING WITH ARYL ISONITRILE | UNIVERSITY OF PITTSBURGH | 2001-06-26 | — | — | US | disclosed |
| US-6239278-B1 | Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH | 2001-05-29 | — | — | US | disclosed |
| US-6211371-B1 | REACTING AN ARYL ISONIRILE WITH AN ISOQUINOLIN-1-ONE COMPOUND | UNIVERSITY OF PITTSBURGH | 2001-04-03 | — | — | US | disclosed |
| US-6034243-A | Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2000-03-07 | — | — | US | disclosed |
| US-5744605-A | ANNULATION; CYCLIZATION | UNIVERSITY OF PITTSBURGH (US) | 1998-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210796-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | CACNA1G, CACNA1I, CACNB2 | TSHR 2720/4885MAPK1 3165/4885HTR3E 3008/4885 |
| US-20010029298-A1 | Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof | CGAS, APEX1, DHPS | TSHR 3838/4885MAPK1 2140/4885HTR3E 4474/4885 |
| US-20160015687-A1 | TETRAZOLE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS | CACNA1G, CACNA1I, CACNB2 | TSHR 2720/4885MAPK1 3165/4885HTR3E 3008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.