Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243057 | 0.91 | CHEK1 (0.37) | CHEK1HPGDKDM4EALDH1A1ESR1 | |
| SCHEMBL3252205 | 0.90 | TTK (0.42) | CHEK1HPGDKDM4EALDH1A1ESR1 | |
| SCHEMBL3245415 | 0.90 | CHEK1 (0.39) | CHEK1HPGDKDM4EALDH1A1ESR1 | |
| SCHEMBL3241975 | 0.89 | MEN1 (0.49) | HPGDALDH1A1HSD17B10KMT2AALOX15 | |
| SCHEMBL3249852 | 0.89 | BRD4 (0.52) | KMT2AMAOASMN1; SMN2MEN1TP53 | |
| SCHEMBL3252529 | 0.89 | ALDH1A1 (0.47) | HPGDKDM4EALDH1A1HSD17B10KMT2A | |
| SCHEMBL3256086 | 0.87 | KDR (0.38) | CHEK1HPGDKDM4EALDH1A1ESR1 | |
| SCHEMBL3254540 | 0.87 | MMP2 (0.46) | CHEK1HPGDKDM4EALDH1A1MMP13 | |
| SCHEMBL13928204 | 0.84 | MMP13 (0.51) | CHEK1HPGDKDM4EALDH1A1ESR1 | |
| SCHEMBL3245727 | 0.84 | GABRA1 (0.50) | HPGDALDH1A1HSD17B10KMT2APRNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |