Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | STK17B | O94768 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249374 | 0.89 | CHEK1 (0.47) | BRD4MAOASMN1; SMN2MEN1KMT2A | |
| SCHEMBL3243057 | 0.86 | CHEK1 (0.37) | BRD4MEN1KMT2ATP53 | |
| SCHEMBL13928203 | 0.85 | BRD4 (0.53) | BRD4MAOAMAOBNPC1SMN1; SMN2 | |
| SCHEMBL3254675 | 0.85 | ALDH1A1 (0.42) | NPC1SMN1; SMN2RAB9AGAAMAPT | |
| SCHEMBL3255483 | 0.84 | BRD4 (0.50) | BRD4SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL3252529 | 0.83 | ALDH1A1 (0.47) | NPC1SMN1; SMN2RAB9AGAAMAPT | |
| SCHEMBL3255334 | 0.83 | BRD4 (0.36) | BRD4MAPTMEN1KMT2ATP53 | |
| SCHEMBL3252380 | 0.83 | CSF1R (0.43) | NPC1SMN1; SMN2RAB9AGAAMAPT | |
| SCHEMBL3249789 | 0.82 | BRD4 (0.53) | BRD4SMN1; SMN2GAAMAPTMEN1 | |
| SCHEMBL3254540 | 0.82 | MMP2 (0.46) | BRD4GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |