Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | OGT | O15294 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250099 | 0.92 | POLB (0.47) | ALDH1A1MAPTTP53POLBOGT | |
| SCHEMBL3253968 | 0.88 | PKM (0.49) | ALDH1A1SMN1; SMN2THRBMAPTTP53 | |
| SCHEMBL3255485 | 0.88 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2THRBMAPTTP53 | |
| SCHEMBL3249389 | 0.87 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2THRBMAPTTP53 | |
| SCHEMBL3249416 | 0.87 | POLB (0.44) | THRBMAPTTP53POLBLMNA | |
| SCHEMBL3249833 | 0.86 | POLB (0.44) | ALDH1A1THRBMAPTTP53POLB | |
| SCHEMBL3249676 | 0.86 | POLB (0.47) | ALDH1A1SMN1; SMN2THRBMAPTTP53 | |
| SCHEMBL3248591 | 0.85 | TAS2R14 (0.43) | ALDH1A1SMN1; SMN2THRBMAPTTP53 | |
| SCHEMBL3243020 | 0.85 | PKM (0.48) | ALDH1A1SMN1; SMN2MAPTTP53POLB | |
| SCHEMBL3249059 | 0.85 | MAPT (0.47) | ALDH1A1SMN1; SMN2MAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |