Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 9/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250099 | 0.89 | POLB (0.47) | POLBTDP1MAPTTP53L3MBTL1 | |
| SCHEMBL3243020 | 0.89 | PKM (0.48) | POLBTDP1MAPTTP53LMNA | |
| SCHEMBL3249858 | 0.88 | HSD17B10 (0.42) | POLBTDP1MAPTTP53LMNA | |
| SCHEMBL3250191 | 0.87 | POLB (0.47) | POLBTDP1MAPTTP53L3MBTL1 | |
| SCHEMBL3249416 | 0.86 | POLB (0.44) | POLBTDP1MAPTTP53L3MBTL1 | |
| SCHEMBL3249397 | 0.86 | ALDH1A1 (0.44) | POLBTDP1MAPTTP53LMNA | |
| SCHEMBL3250772 | 0.86 | HTT (0.42) | POLBKMT2APKMMEN1MAPK1 | |
| SCHEMBL3245542 | 0.85 | ALDH1A1 (0.42) | POLBTDP1MAPTTP53LMNA | |
| SCHEMBL3248591 | 0.84 | TAS2R14 (0.43) | POLBTDP1MAPTTP53L3MBTL1 | |
| SCHEMBL3248921 | 0.84 | ALDH1A1 (0.41) | MAPTTP53L3MBTL1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |