Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 5/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3245670 | 0.87 | CSF1R (0.37) | GABRA1GABRA3GABRG2GABRB3GABRA5 | |
| SCHEMBL3245150 | 0.86 | GABRA1 (0.50) | GABRA1GABRA3GABRG2GABRB3GABRA5 | |
| SCHEMBL3249647 | 0.84 | CHEK1 (0.37) | ALDH1A1HPGDHSD17B10MEN1TP53 | |
| SCHEMBL3255332 | 0.84 | ADORA3 (0.40) | GABRA1GABRA3ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3245727 | 0.84 | GABRA1 (0.50) | GABRA1GABRA3ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3252529 | 0.84 | ALDH1A1 (0.47) | GABRA1GABRA3ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3248921 | 0.84 | ALDH1A1 (0.41) | GABRA1ALDH1A1HPGDHSD17B10MEN1 | |
| SCHEMBL3255435 | 0.83 | GABRA1 (0.45) | GABRA1GABRA3GABRG2GABRB3GABRA5 | |
| SCHEMBL3250586 | 0.82 | HSD17B10 (0.37) | GABRA1GABRA3ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3243057 | 0.82 | CHEK1 (0.37) | GABRA1GABRA3ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |