Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 4/20 | 0.32 |
| ▸ | ACE | P12821 | 4/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5740073 | 0.86 | PDE5A (0.37) | CYP2D6MAPTGAAKDM4EALDH1A1 | |
| SCHEMBL9631444 | 0.77 | MAPT (0.47) | CYP2D6MAPTGAAKDM4ESMN1; SMN2 | |
| SCHEMBL10505998 | 0.77 | MAPT (0.47) | CYP2D6MAPTGAAKDM4ESMN1; SMN2 | |
| SCHEMBL5319112 | 0.76 | SLC22A1 (0.50) | CYP2D6MAPTGAAKDM4ESMN1; SMN2 | |
| SCHEMBL917364 | 0.74 | ALDH1A1 (0.52) | MAPTGAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7995094 | 0.72 | ALDH1A1 (0.36) | MAPTGAAALDH1A1TSHRMEN1 | |
| SCHEMBL31650932 | 0.70 | MAPT (0.53) | CYP2D6MAPTGAAKDM4ESMN1; SMN2 | |
| SCHEMBL268492 | 0.70 | MAPT (0.53) | CYP2D6MAPTGAAKDM4ESMN1; SMN2 | |
| SCHEMBL28787105 | 0.70 | MAPT (0.53) | CYP2D6MAPTGAAKDM4ESMN1; SMN2 | |
| SCHEMBL29430156 | 0.70 | MAPT (0.53) | CYP2D6MAPTGAAKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227803-B1 | COMPOUNDS FOR INHIBITING IAPP-ASSOCIATED AMYLOID DEPOSITS | BELLUS HEALTH INTERNATIONAL LTD (CH) | 2010-05-05 | — | — | EP | claimed |
| US-6562836-B1 | Islet amyloid polypeptide (IAPP) is known to be capable of forming fibrils which are deposited in the pancreas of patients wtih type II diabetes | QUEEN'S UNIVERSITY OF KINGSTON (CA) | 2003-05-13 | — | — | US | claimed |