Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246877 | 0.77 | TSHR (0.44) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL2074396 | 0.76 | KCNN4 (0.48) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL6399480 | 0.75 | TSHR (0.52) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL1549012 | 0.73 | HDAC3 (0.45) | ALDH1A1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6170218 | 0.73 | KCNN4 (0.44) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL3114470 | 0.73 | HDAC3 (0.45) | ALDH1A1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3246081 | 0.73 | TSHR (0.44) | TSHRALDH1A1PTPN1CA1CA2 | |
| SCHEMBL3237952 | 0.72 | KCNN4 (0.37) | ALDH1A1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL3665471 | 0.70 | HDAC3 (0.47) | ALDH1A1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL874380 | 0.69 | TSHR (0.50) | TSHRALDH1A1PTPN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4249077-A1 | NOVEL ACRIDINIUM SALT AND METHOD FOR PRODUCING SAME | Shionogi & Co., Ltd (JP) | 2023-09-27 | — | — | EP | disclosed |
| US-20230278960-A1 | NOVEL ACRIDINIUM SALT AND METHOD FOR PRODUCING SAME | SHIONOGI & CO., LTD. (JP) | 2023-09-07 | — | — | US | disclosed |
| CN-111386276-B | Stereoselective process for preparing substituted polycyclic pyridone derivatives | 盐野义制药株式会社 | 2023-06-23 | — | — | CN | disclosed |
| US-20230040262-A1 | STEREOSELECTIVE PROCESS FOR PREPARING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2023-02-09 | — | — | US | disclosed |
| EP-3693373-A1 | METHOD FOR STEREOSELECTIVELY PRODUCING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVE | Shionogi&Co., Ltd. (JP) | 2020-08-12 | — | — | EP | disclosed |
| US-20200247818-A1 | STEREOSELECTIVE PROCESS FOR PREPARING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2020-08-06 | — | — | US | disclosed |
| CN-111386276-A | Stereoselective process for preparing substituted polycyclic pyridone derivatives | 盐野义制药株式会社 | 2020-07-07 | — | — | CN | disclosed |
| EP-1167366-B1 | AMINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2010-05-05 | — | — | EP | disclosed |
| US-6562849-B1 | Amine compound or pharmacologically acceptable salt thereof. These compounds are useful in the treatment and/or prophylaxis of diseases such as diabetes, hyperlipemia, arteriosclerosis, cancer, etc. | SANKYO COMPANY, LIMITED (JP) | 2003-05-13 | — | — | US | disclosed |
| US-20030078426-A1 | Amine derivative compounds | SANKYO COMPANY, LIMITED (JP) | 2003-04-24 | — | — | US | disclosed |
| EP-1167366-A1 | AMINE DERIVATIVES | Sankyo Company, Limited (JP) | 2002-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247818-A1 | STEREOSELECTIVE PROCESS FOR PREPARING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES | RNGTT, CPSF6, ENDOD1 | TSHR 3217/4885ALDH1A1 1645/4885PTPN1 3799/4885 |
| US-20230278960-A1 | NOVEL ACRIDINIUM SALT AND METHOD FOR PRODUCING SAME | ATL3, CBR3, CLIC1 | TSHR 762/4885ALDH1A1 1673/4885PTPN1 3493/4885 |
| US-20230040262-A1 | STEREOSELECTIVE PROCESS FOR PREPARING SUBSTITUTED POLYCYCLIC PYRIDONE DERIVATIVES | RNGTT, CPSF6, RNASEL | TSHR 3169/4885ALDH1A1 1711/4885PTPN1 3780/4885 |
| US-20030078426-A1 | Amine derivative compounds | H1-10, APOB, PRMT1 | TSHR 2306/4885ALDH1A1 874/4885PTPN1 2354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.