Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.51 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247032 | 1.00 | OPRK1 (0.51) | OPRK1NPY1RHTTNPY2ROPRL1 | |
| SCHEMBL3252831 | 0.97 | OPRK1 (0.54) | OPRK1NPY1RHTTNPY2ROPRL1 | |
| SCHEMBL3252835 | 0.97 | OPRK1 (0.54) | OPRK1NPY1RHTTNPY2ROPRL1 | |
| SCHEMBL168288 | 0.77 | SIGMAR1 (0.38) | OPRK1ALDH1A1SIGMAR1 | |
| SCHEMBL7808275 | 0.77 | SIGMAR1 (0.40) | OPRK1ALDH1A1SIGMAR1 | |
| SCHEMBL8947196 | 0.72 | KDM4E (0.45) | ALDH1A1POLBSIGMAR1 | |
| SCHEMBL10913905 | 0.72 | OPRK1 (0.44) | OPRK1HTTALDH1A1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9837514 | 0.72 | KMT2A (0.40) | OPRK1ALDH1A1 | |
| SCHEMBL11149436 | 0.71 | OPRK1 (0.46) | OPRK1HTTALDH1A1SIGMAR1 | |
| SCHEMBL7456872 | 0.71 | LMNA (0.42) | OPRK1ALDH1A1POLBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888345-B1 | SIGMA-2 RECEPTORS AS BIOMARKERS OF TUMOR CELL PROLIFERATION | UNIV WAKE FOREST HEALTH SCIENCES (US) | 2010-05-05 | — | — | EP | disclosed |
| US-6676925-B1 | BINDING WITH 9-AZABICYCLO(3.3.1)NONANE DERIVATIVES DETECTIVELY LABELED FOR POSITRON OR SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY IMAGING | WAKE FOREST UNIVERSITY | 2004-01-13 | — | — | US | disclosed |
| EP-0888345-A4 | SIGMA-2 RECEPTORS AS BIOMARKERS OF TUMOR CELL PROLIFERATION | UNIV WAKE FOREST (US) | 2001-06-27 | — | — | EP | disclosed |
| US-6113877-A | ADMINISTERING 8-AZABICYCLO(3.2.1)OCTANE OR 9-AZABICYCLO(3.3.1)NONANE DERIVATIVES; DETERMINING BREAST CANCER THERAPY | WAKE FOREST UNIVERSITY (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0888345-A1 | SIGMA-2 RECEPTORS AS BIOMARKERS OF TUMOR CELL PROLIFERATION | WAKE FOREST UNIVERSITY (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034892-A1 | SIGMA-2 RECEPTORS AS BIOMARKERS OF TUMOR CELL PROLIFERATION | WAKE FOREST UNIVERSITY (US) | 1997-09-25 | — | — | WO | disclosed |