Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11098245 | 0.78 | OPRM1 (0.48) | OPRK1 | |
| SCHEMBL7458612 | 0.75 | OPRM1 (0.34) | — | |
| SCHEMBL11207221 | 0.74 | LMNA (0.39) | LMNAPOLBOPRK1ACHEBACE1 | |
| SCHEMBL10913138 | 0.74 | LMNA (0.41) | LMNAPOLBOPRK1ACHEBACE1 | |
| SCHEMBL3247032 | 0.71 | OPRK1 (0.51) | POLBOPRK1ALDH1A1SIGMAR1 | |
| SCHEMBL168288 | 0.71 | SIGMAR1 (0.38) | OPRK1ACHEALDH1A1SIGMAR1 | |
| SCHEMBL3250253 | 0.71 | OPRK1 (0.51) | POLBOPRK1ALDH1A1SIGMAR1 | |
| SCHEMBL7808275 | 0.70 | SIGMAR1 (0.40) | OPRK1ACHEALDH1A1SIGMAR1 | |
| SCHEMBL3252835 | 0.70 | OPRK1 (0.54) | POLBOPRK1ALDH1A1SIGMAR1 | |
| SCHEMBL3252831 | 0.70 | OPRK1 (0.54) | POLBOPRK1ALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944626-A4 | TROPANE DERIVATIVES AND METHOD FOR THEIR SYNTHESIS | UNIV GEORGETOWN (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-0944626-A1 | TROPANE DERIVATIVES AND METHOD FOR THEIR SYNTHESIS | GEORGETOWN UNIVERSITY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998024788-A1 | TROPANE DERIVATIVES AND METHOD FOR THEIR SYNTHESIS | GEORGETOWN UNIVERSITY (US) | 1998-06-11 | — | — | WO | disclosed |