Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253367 | 0.90 | KDM1A (0.35) | CHRM5CHRM1CHRM3TP53GAA | |
| SCHEMBL3253146 | 0.85 | SMN1; SMN2 (0.37) | TP53GAARAB9A | |
| SCHEMBL3256757 | 0.85 | RPA1 (0.34) | GAARAB9A | |
| SCHEMBL3255809 | 0.84 | SLC6A2 (0.41) | CHRM1CHRM3CHRM2TP53GAA | |
| SCHEMBL3254057 | 0.84 | TP53 (0.42) | TP53GAARAB9AP2RX7 | |
| SCHEMBL3252454 | 0.84 | ROCK2 (0.35) | TP53GAARAB9A | |
| SCHEMBL3256637 | 0.84 | TACR1 (0.35) | TP53GAARAB9AP2RX7 | |
| SCHEMBL3255000 | 0.83 | P2RX7 (0.43) | TP53P2RX7 | |
| SCHEMBL3256042 | 0.82 | P2RX7 (0.39) | GAARAB9AP2RX7 | |
| SCHEMBL3256725 | 0.81 | GAA (0.33) | TP53GAARAB9AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |