Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3259233 | 0.90 | P2RX7 (0.41) | P2RX7PKMALDH1A1LMNAPPARG | |
| SCHEMBL3255809 | 0.87 | SLC6A2 (0.41) | PKMTP53 | |
| SCHEMBL3254057 | 0.87 | TP53 (0.42) | P2RX7TP53 | |
| SCHEMBL3249024 | 0.87 | KMT2A (0.41) | P2RX7ALDH1A1LMNA | |
| SCHEMBL3259173 | 0.86 | ALDH1A1 (0.39) | P2RX7PKMALDH1A1LMNATP53 | |
| SCHEMBL3253367 | 0.86 | KDM1A (0.35) | ALDH1A1TP53SIGMAR1 | |
| SCHEMBL3257493 | 0.85 | ALDH1A1 (0.38) | P2RX7PKMALDH1A1LMNA | |
| SCHEMBL3255278 | 0.84 | SIGMAR1 (0.35) | P2RX7TP53SIGMAR1 | |
| SCHEMBL3256724 | 0.84 | P2RX7 (0.39) | P2RX7PKMALDH1A1LMNAHCAR2 | |
| SCHEMBL3254884 | 0.84 | SIGMAR1 (0.35) | ALDH1A1PPARGTP53SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |