Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3257493 | 0.90 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1 | |
| SCHEMBL3256757 | 0.90 | RPA1 (0.34) | GAARAB9AGRM2GRM3 | |
| SCHEMBL3253979 | 0.90 | CHRM5 (0.36) | CHRM5CHRM1CHRM3TP53GAA | |
| SCHEMBL3254057 | 0.87 | TP53 (0.42) | KDM1AL3MBTL1TP53GAARAB9A | |
| SCHEMBL3255000 | 0.86 | P2RX7 (0.43) | SIGMAR1ALDH1A1TP53 | |
| SCHEMBL3255018 | 0.86 | GAA (0.35) | ALDH1A1TP53GAARAB9ASMN1; SMN2 | |
| SCHEMBL3255278 | 0.84 | SIGMAR1 (0.35) | KDM1ASIGMAR1TP53GAAHTT | |
| SCHEMBL3256725 | 0.83 | GAA (0.33) | KDM1ASIGMAR1TP53GAARAB9A | |
| SCHEMBL3253146 | 0.83 | SMN1; SMN2 (0.37) | ALDH1A1L3MBTL1TP53GAARAB9A | |
| SCHEMBL3258687 | 0.83 | GPBAR1 (0.39) | KDM1ASIGMAR1TSHRGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |