Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3258350 | 0.90 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3CACNA1BATM | |
| SCHEMBL3255000 | 0.87 | P2RX7 (0.43) | PKMTP53 | |
| SCHEMBL3253146 | 0.87 | SMN1; SMN2 (0.37) | ATMRAB9AMEN1KMT2AGAA | |
| SCHEMBL3253979 | 0.84 | CHRM5 (0.36) | RAB9ACHRM2CHRM3GAATP53 | |
| SCHEMBL3253367 | 0.83 | KDM1A (0.35) | RAB9ACHRM3GAATP53CHRM1 | |
| SCHEMBL3256042 | 0.81 | P2RX7 (0.39) | ATMRAB9ACTBP2GAA | |
| SCHEMBL3254057 | 0.81 | TP53 (0.42) | SLC6A2SLC6A4SLC6A3ATMRAB9A | |
| SCHEMBL3250310 | 0.81 | P2RX7 (0.40) | CACNA1BPKM | |
| SCHEMBL3258687 | 0.80 | GPBAR1 (0.39) | ATMKMT2AGAA | |
| SCHEMBL3256725 | 0.80 | GAA (0.33) | RAB9AGAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |