Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3251108 | 0.92 | ALDH1A1 (0.43) | MAPTTP53RXFP1POLBKDM4E | |
| SCHEMBL3247465 | 0.88 | CRHBP (0.47) | MAPTTP53POLBKDM4EALDH1A1 | |
| SCHEMBL3247431 | 0.88 | MAPT (0.48) | MAPTTP53RXFP1POLBKDM4E | |
| SCHEMBL3254915 | 0.86 | MAPT (0.47) | MAPTTP53RXFP1POLBKDM4E | |
| SCHEMBL3255978 | 0.86 | FEN1 (0.39) | MAPTTP53RXFP1POLBKDM4E | |
| SCHEMBL3241840 | 0.83 | KDM4E (0.41) | MAPTTP53RXFP1POLBKDM4E | |
| SCHEMBL3241913 | 0.82 | KDM4E (0.51) | MAPTTP53RXFP1POLBKDM4E | |
| SCHEMBL3251841 | 0.82 | MAPT (0.51) | MAPTTP53RXFP1POLBKDM4E | |
| SCHEMBL3250557 | 0.82 | MAPT (0.41) | MAPTTP53POLBKDM4EALDH1A1 | |
| SCHEMBL3253968 | 0.82 | PKM (0.49) | MAPTTP53POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |