Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250741 | 0.88 | MAPT (0.55) | MAPTPKMGAAALDH1A1MEN1 | |
| SCHEMBL3253160 | 0.83 | MEN1 (0.51) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL3252092 | 0.83 | KMT2A (0.50) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3241840 | 0.83 | KDM4E (0.41) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3249322 | 0.81 | MAPT (0.54) | MAPTPKMGAAALDH1A1MEN1 | |
| SCHEMBL3251774 | 0.81 | CASP3 (0.52) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL4154862 | 0.80 | PKM (0.49) | MAPTPKMGAAALDH1A1MEN1 | |
| SCHEMBL3250557 | 0.80 | MAPT (0.41) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3255978 | 0.79 | FEN1 (0.39) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL3250842 | 0.79 | KDM4E (0.44) | MAPTGAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |