Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252092 | 0.88 | KMT2A (0.50) | KDM4EKMT2AMEN1POLBCYP2C9 | |
| SCHEMBL3251347 | 0.87 | KMT2A (0.46) | KDM4EKMT2AMEN1POLBCYP2C9 | |
| SCHEMBL3253160 | 0.86 | MEN1 (0.51) | KDM4EKMT2AMEN1POLBCYP2C9 | |
| SCHEMBL3251774 | 0.85 | CASP3 (0.52) | KDM4EKMT2AMEN1POLBCYP2C9 | |
| SCHEMBL3241840 | 0.84 | KDM4E (0.41) | KDM4EKMT2AMEN1POLBCYP2C9 | |
| SCHEMBL3250557 | 0.83 | MAPT (0.41) | KDM4EKMT2AMEN1POLBCYP2C9 | |
| SCHEMBL3247431 | 0.81 | MAPT (0.48) | KDM4EKMT2AMEN1POLBCYP2C9 | |
| SCHEMBL3248591 | 0.81 | TAS2R14 (0.43) | KDM4EKMT2AMEN1POLBCYP2C9 | |
| SCHEMBL3250591 | 0.81 | PARG (0.48) | KDM4EKMT2AMEN1POLBCYP2C9 | |
| SCHEMBL3250743 | 0.81 | KDM4E (0.39) | KDM4EKMT2AMEN1POLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |