Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.35 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.35 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.35 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGFR | P43088 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3251176 | 0.90 | ALDH1A1 (0.35) | PDPK1TRPV1TSHRSIGMAR1 | |
| SCHEMBL3255825 | 0.88 | PDPK1 (0.36) | PDPK1MEN1KMT2A | |
| SCHEMBL3258394 | 0.87 | P2RX7 (0.42) | PLAAT3PLAAT5PLAAT2PLAAT4TRPV1 | |
| SCHEMBL3258744 | 0.84 | P2RX7 (0.38) | PLAAT3PLAAT5PLAAT2PLAAT4MEN1 | |
| SCHEMBL3253810 | 0.84 | ALDH1A1 (0.41) | PLAAT3PLAAT5PLAAT2PLAAT4MEN1 | |
| SCHEMBL3256757 | 0.84 | RPA1 (0.34) | — | |
| SCHEMBL3259233 | 0.84 | P2RX7 (0.41) | CHRM3CHRM2 | |
| SCHEMBL3258306 | 0.84 | P2RX7 (0.39) | PLAAT3PLAAT5PLAAT2PLAAT4TRPV1 | |
| SCHEMBL3258633 | 0.84 | PDPK1 (0.41) | PDPK1PLAAT3PLAAT5PLAAT2PLAAT4 | |
| SCHEMBL3258350 | 0.83 | SLC6A2 (0.39) | MEN1KMT2ACHRM3CHRM2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |