Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 7/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3256724 | 0.94 | P2RX7 (0.39) | P2RX7PKMTAAR1ALDH1A1LMNA | |
| SCHEMBL3255000 | 0.90 | P2RX7 (0.43) | P2RX7PKMALDH1A1LMNAHCAR2 | |
| SCHEMBL3258350 | 0.88 | SLC6A2 (0.39) | CHRM2CHRM3GPR52 | |
| SCHEMBL3258394 | 0.88 | P2RX7 (0.42) | P2RX7TAAR1ALDH1A1HCAR2CHRM2 | |
| SCHEMBL3258744 | 0.88 | P2RX7 (0.38) | P2RX7ALDH1A1LMNA | |
| SCHEMBL3250310 | 0.88 | P2RX7 (0.40) | P2RX7PKMALDH1A1LMNA | |
| SCHEMBL3248358 | 0.87 | ALDH1A1 (0.38) | P2RX7PKMALDH1A1LMNA | |
| SCHEMBL3251176 | 0.85 | ALDH1A1 (0.35) | P2RX7ALDH1A1LMNA | |
| SCHEMBL3253025 | 0.84 | PAX8 (0.39) | PKMALDH1A1 | |
| SCHEMBL3257729 | 0.84 | ALDH1A1 (0.40) | P2RX7PKMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |