Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.36 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.36 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.36 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253134 | 0.90 | HSD11B1 (0.39) | P2RX7ALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL3259233 | 0.88 | P2RX7 (0.41) | P2RX7ALDH1A1TAAR1HCAR2CHRM2 | |
| SCHEMBL3255825 | 0.88 | PDPK1 (0.36) | ALDH1A1KMT2AMEN1TAAR1POLB | |
| SCHEMBL3258561 | 0.87 | PDPK1 (0.39) | KMT2AMEN1TRPV1ATMPLAAT3 | |
| SCHEMBL3258350 | 0.87 | SLC6A2 (0.39) | KMT2AMEN1ATMGRM2GRM3 | |
| SCHEMBL3256724 | 0.83 | P2RX7 (0.39) | P2RX7ALDH1A1TAAR1HCAR2 | |
| SCHEMBL3258744 | 0.82 | P2RX7 (0.38) | P2RX7ALDH1A1KMT2AMEN1PLAAT3 | |
| SCHEMBL3253810 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KMT2AMEN1SMN1; SMN2PLAAT3 | |
| SCHEMBL3253833 | 0.82 | CES1 (0.41) | P2RX7SMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL3258306 | 0.81 | P2RX7 (0.39) | P2RX7ALDH1A1HPGDTRPV1PLAAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |