Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 3/20 | 0.48 |
| ▸ | CTSA | P10619 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10129965 | 0.83 | PIK3C3 (0.43) | SORT1CTSAPIK3C3FFAR4BRAF | |
| SCHEMBL2635853 | 0.80 | ALDH1A1 (0.56) | SORT1NR3C2BTKKDRALDH1A1 | |
| SCHEMBL31264157 | 0.80 | ALDH1A1 (0.56) | SORT1NR3C2BTKKDRALDH1A1 | |
| SCHEMBL25378471 | 0.76 | MAPK14 (0.42) | SORT1PIK3C3MAPK14NR3C2BRAF | |
| SCHEMBL14891241 | 0.73 | CTSA (0.42) | CTSAFFAR4MPL | |
| SCHEMBL2640650 | 0.73 | NOS3 (0.63) | SORT1NR3C2BTKKDRALDH1A1 | |
| SCHEMBL13382940 | 0.72 | MPL (0.45) | CTSAFFAR4MPL | |
| SCHEMBL1094734 | 0.72 | TOP2A (0.44) | PIK3C3MAPK14NR3C2ABL1 | |
| SCHEMBL29531918 | 0.71 | WNT3A (0.50) | PIK3C3ABL1 | |
| SCHEMBL27220588 | 0.71 | TGFBR1 (0.49) | PIK3C3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590957-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-12 | — | — | EP | disclosed |
| EP-2590957-A2 | CHEMICAL COMPOUNDS | Pfizer Limited (GB) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004714-A2 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2012-01-12 | — | — | WO | disclosed |