Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 7/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.30 |
| ▸ | CTSV | O60911 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15397619 | 0.79 | GLS (0.39) | LMNAPOLBMAPK1ALDH1A1KDM4E | |
| SCHEMBL2299075 | 0.79 | GLS (0.42) | LMNAPOLBSMN1; SMN2 | |
| SCHEMBL12385385 | 0.76 | PCSK9 (0.36) | POLBMAPK1CTSLCTSBCTSS | |
| SCHEMBL4379140 | 0.70 | AKT1 (0.40) | LMNAMAPK1ALDH1A1CTSA | |
| SCHEMBL4541679 | 0.67 | AKT1 (0.41) | ITGB1ITGA2ALDH1A1KDM4ERAB9A | |
| SCHEMBL4541274 | 0.66 | STAT3 (0.36) | LMNAMAPK1CTSAHDAC8CTSV | |
| SCHEMBL4554357 | 0.65 | RORC (0.46) | LMNAPOLBITGB1ALDH1A1NPC1 | |
| SCHEMBL4440845 | 0.65 | HDAC1 (0.53) | LMNAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4554171 | 0.64 | DHPS (0.42) | LMNAMAPK1ALDH1A1SMN1; SMN2CTSA | |
| SCHEMBL2299249 | 0.64 | ALDH1A1 (0.35) | LMNAFFAR2ITGB1ITGA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045309-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-04-22 | — | — | WO | disclosed |