SCHEMBL3260152

SCHEMBL3260152

CC1CON=C(c2cnn(C)c2SCc2ccccc2)O1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.39
GAA P10253 2/20 0.39
PKM P14618 2/20 0.39
ALDH1A1 P00352 5/20 0.35
SMN1; SMN2 Q16637 4/20 0.33
LMNA P02545 3/20 0.33
RAB9A P51151 3/20 0.33
HPGD P15428 2/20 0.33
PPARG P37231 2/20 0.33
HTT P42858 2/20 0.33
NCOA2 Q15596 2/20 0.33
NCOA1 Q15788 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
KDM4E B2RXH2 2/20 0.33
MAPK1 P28482 1/20 0.32
AR P10275 1/20 0.32
NPC1 O15118 3/20 0.32
METAP2 P50579 1/20 0.32
CYP3A4 P08684 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3259110 0.86 GAA (0.39) MAPTGAAPKMALDH1A1SMN1; SMN2
SCHEMBL8629590 0.80 MAPT (0.41) MAPTGAAPKMALDH1A1SMN1; SMN2
SCHEMBL3259559 0.79 MAPT (0.34) MAPTGAAPKMALDH1A1SMN1; SMN2
SCHEMBL3258983 0.78 MAPT (0.35) MAPTGAAPKMALDH1A1SMN1; SMN2
SCHEMBL18215173 0.68 MAPT (0.50) MAPTGAAPKMALDH1A1SMN1; SMN2
SCHEMBL15542730 0.68 MAPT (0.42) MAPTGAAPKMALDH1A1SMN1; SMN2
SCHEMBL15553774 0.68 L3MBTL1 (0.51) MAPTGAAPKMALDH1A1SMN1; SMN2
SCHEMBL15542874 0.68 GAA (0.40) MAPTGAAPKMALDH1A1SMN1; SMN2
SCHEMBL15554549 0.67 MAPT (0.41) MAPTGAAPKMALDH1A1SMN1; SMN2
SCHEMBL23863535 0.67 MAPT (0.52) MAPTGAAPKMALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7709636-B2 Pyrazole sulfonylurea compound and herbicide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-05-04 US disclosed
US-7709636-B2 Pyrazole sulfonylurea compound and herbicide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-05-04 US disclosed
US-20100016584-A1 Pyrazole sulfonylurea compound and herbicide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-01-21 US disclosed
US-20100016584-A1 Pyrazole sulfonylurea compound and herbicide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-01-21 US disclosed
US-7557067-B2 Pyrazole sulfonylurea compound and herbicide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-07-07 US disclosed
US-7557067-B2 Pyrazole sulfonylurea compound and herbicide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-07-07 US disclosed
US-20080064600-A1 Pyrazole Sulfonylurea Compound and Herbicide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2008-03-13 US disclosed
US-20080064600-A1 Pyrazole Sulfonylurea Compound and Herbicide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2008-03-13 US disclosed
EP-1748047-A1 PYRAZOLE SULFONYLUREA COMPOUND AND HERBICIDE Nissan Chemical Industries, Ltd. (JP) 2007-01-31 EP disclosed
EP-1748047-A1 PYRAZOLE SULFONYLUREA COMPOUND AND HERBICIDE Nissan Chemical Industries, Ltd. (JP) 2007-01-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100016584-A1 Pyrazole sulfonylurea compound and herbicide PDXK, HCN3, SLC6A9 MAPT 4591/4885GAA 2575/4885PKM 703/4885
US-20080064600-A1 Pyrazole Sulfonylurea Compound and Herbicide GLP1R, MSRB3, PDXK MAPT 4685/4885GAA 2715/4885PKM 1156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.