Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 4/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2359649 | 0.87 | LMNA (0.35) | TAAR1HSD11B1LMNANPSR1KIF11 | |
| SCHEMBL14032263 | 0.84 | AGTR1 (0.35) | HSD11B1LMNANPSR1AGTR1AGTR2 | |
| SCHEMBL22615880 | 0.84 | HSD11B1 (0.36) | HSD11B1LMNANPSR1AGTR1AGTR2 | |
| SCHEMBL838908 | 0.81 | SLC9A1 (0.36) | HSD11B1LMNANPSR1AGTR1AGTR2 | |
| SCHEMBL8418644 | 0.81 | DAGLA (0.35) | HSD11B1LMNANPSR1AGTR1AGTR2 | |
| SCHEMBL7202719 | 0.81 | DAGLA (0.35) | HSD11B1LMNANPSR1AGTR1AGTR2 | |
| SCHEMBL3568399 | 0.80 | SLC9A1 (0.35) | HSD11B1LMNANPSR1AGTR1AGTR2 | |
| SCHEMBL8417361 | 0.80 | DAGLA (0.34) | HSD11B1LMNANPSR1AGTR1AGTR2 | |
| SCHEMBL1121488 | 0.80 | LMNA (0.35) | HSD11B1LMNANPSR1AGTR1AGTR2 | |
| SCHEMBL5357964 | 0.80 | LMNA (0.35) | HSD11B1LMNANPSR1AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160368919-A1 | NOVEL PYRIDINE PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2016-12-22 | — | — | US | disclosed |
| WO-2016203335-A1 | NOVEL PYRIDO[2,3-B]PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | PFIZER INC. (US) | 2016-12-22 | — | — | WO | disclosed |
| WO-2010022249-A2 | MACROCYCLIC COMPOUNDS FOR INHIBITION OF TUMOR NECROSIS FACTOR ALPHA | ENSEMBLE DISCOVERY CORPORATION (US) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368919-A1 | NOVEL PYRIDINE PYRAZINONES AS BET-FAMILY BROMODOMAIN INHIBITORS | BRD4, BRD3, BET1 | CYP2A6 3346/4885HTR2A 3795/4885SMN1; SMN2 4137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.