Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 15/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9972900 | 0.68 | ALDH1A1 (0.44) | TRPA1ALDH1A1LMNAMAPT | |
| SCHEMBL3263348 | 0.67 | TRPA1 (0.36) | TRPA1TRPV4 | |
| SCHEMBL3264313 | 0.65 | TRPA1 (0.36) | TRPA1TRPV4 | |
| SCHEMBL13537668 | 0.63 | TRPA1 (0.50) | TRPA1TRPV4 | |
| SCHEMBL1801079 | 0.62 | PIK3CD (0.46) | ALDH1A1MAPT | |
| SCHEMBL3264317 | 0.62 | FFAR2 (0.47) | TRPA1HSD17B10LMNAHTT | |
| SCHEMBL20886848 | 0.61 | GRM4 (0.47) | KDM4EALDH1A1HSD17B10BRD4BRPF1 | |
| SCHEMBL3234692 | 0.60 | TRPA1 (0.50) | TRPA1TRPV4 | |
| SCHEMBL22904134 | 0.60 | MAPT (0.46) | TRPA1TRPV4ALDH1A1BRPF1MAPT | |
| SCHEMBL1801280 | 0.60 | PIK3CD (0.46) | TRPA1KDM4EALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010004390-A1 | QUINAZOLINE DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-01-14 | — | — | WO | disclosed |