Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 18/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263348 | 0.80 | TRPA1 (0.36) | TRPA1TRPV4TRPV3NPC1PKM | |
| SCHEMBL3264317 | 0.72 | FFAR2 (0.47) | TRPA1NPC1PKM | |
| SCHEMBL3266992 | 0.71 | CNR2 (0.35) | TRPA1NPC1PKM | |
| SCHEMBL9972900 | 0.66 | ALDH1A1 (0.44) | TRPA1 | |
| SCHEMBL3266719 | 0.65 | KMT2A (0.35) | — | |
| SCHEMBL3264475 | 0.65 | TRPA1 (0.33) | TRPA1TRPV4 | |
| SCHEMBL13537668 | 0.64 | TRPA1 (0.50) | TRPA1TRPV4TRPV3 | |
| SCHEMBL4026302 | 0.64 | FDPS (0.51) | PKMFDPS | |
| SCHEMBL9960985 | 0.62 | NPC1 (0.36) | NPC1PKM | |
| SCHEMBL21299172 | 0.62 | FDPS (0.53) | PKMFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010004390-A1 | QUINAZOLINE DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-01-14 | — | — | WO | claimed |
| WO-2010004390-A1 | QUINAZOLINE DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2010-01-14 | — | — | WO | disclosed |