Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL118040 | 1.00 | LMNA (0.40) | LMNASMN1; SMN2CYP3A4SLC6A4CHRM2 | |
| SCHEMBL13953706 | 0.88 | CYP3A4 (0.38) | LMNASMN1; SMN2CYP3A4SLC6A4CHRM2 | |
| SCHEMBL16791656 | 0.86 | SMN1; SMN2 (0.42) | LMNASMN1; SMN2CYP3A4SLC6A4CHRM2 | |
| SCHEMBL15674698 | 0.84 | SMN1; SMN2 (0.40) | LMNASMN1; SMN2CYP3A4SLC6A4CHRM2 | |
| SCHEMBL117417 | 0.84 | SMN1; SMN2 (0.40) | LMNASMN1; SMN2CYP3A4SLC6A4CHRM2 | |
| SCHEMBL10066477 | 0.84 | SMN1; SMN2 (0.40) | LMNASMN1; SMN2CYP3A4SLC6A4CHRM2 | |
| SCHEMBL3192627 | 0.77 | SIGMAR1 (0.39) | LMNASMN1; SMN2CYP3A4SLC6A4CHRM2 | |
| SCHEMBL1850432 | 0.77 | DRD2 (0.43) | SMN1; SMN2OPRM1DRD3KMT2AMEN1 | |
| SCHEMBL1902599 | 0.74 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2CYP3A4SLC6A4CHRM2 | |
| SCHEMBL5468813 | 0.73 | LMNA (0.61) | LMNASMN1; SMN2CYP3A4SLC6A4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010157-A2 | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-28 | — | — | WO | disclosed |