Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.36 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.36 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.36 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9954703 | 0.84 | DRD2 (0.44) | DRD2DRD4OPRM1DRD3FDPS | |
| SCHEMBL3264659 | 0.77 | LMNA (0.40) | OPRM1DRD3MEN1KMT2AATM | |
| SCHEMBL118040 | 0.77 | LMNA (0.40) | OPRM1DRD3MEN1KMT2AATM | |
| SCHEMBL1027242 | 0.73 | PLAAT3 (0.40) | DRD2DRD4OPRM1DRD3TAAR1 | |
| SCHEMBL1692344 | 0.72 | KCNN4 (0.43) | TAAR1SMN1; SMN2 | |
| SCHEMBL29602871 | 0.70 | TAAR1 (0.55) | DRD2DRD4DRD3TAAR1MEN1 | |
| SCHEMBL958756 | 0.69 | DRD2 (0.54) | DRD2DRD4OPRM1DRD3FDPS | |
| SCHEMBL5704134 | 0.69 | LMNA (0.42) | MEN1KMT2APLAAT3PLAAT5PLAAT2 | |
| SCHEMBL5640773 | 0.69 | CHRM3 (0.44) | OPRM1TAAR1MEN1KMT2AHTR2A | |
| SCHEMBL27526941 | 0.68 | TAAR1 (0.57) | GPBAR1TAAR1MEN1KMT2AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324017-A2 | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 | Boehringer Ingelheim International GmbH (DE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010010157-A2 | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-01-28 | — | — | WO | disclosed |