SCHEMBL3265231

SCHEMBL3265231

Cc1cc2ccc(C(C)C)cc2[nH]1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EIF4A3 P38919 3/20 0.57
KIF11 P52732 1/20 0.46
SCN10A Q9Y5Y9 1/20 0.44
PTGS2 P35354 1/20 0.43
CYP2A6 P11509 1/20 0.41
KEAP1 Q14145 1/20 0.41
LMNA P02545 2/20 0.41
TRPA1 O75762 1/20 0.39
PTGS1 P23219 1/20 0.39
CACNA1C Q13936 1/20 0.39
AXL P30530 1/20 0.39
AURKA O14965 1/20 0.38
DAPK3 O43293 1/20 0.38
JAK2 O60674 1/20 0.38
MAP4K4 O95819 1/20 0.38
PAK4 O96013 1/20 0.38
ABL1 P00519 1/20 0.38
LCK P06239 1/20 0.38
FYN P06241 1/20 0.38
CSF1R P07333 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9910163 0.84 CYP2A6 (0.55) EIF4A3KIF11SCN10APTGS2CYP2A6
SCHEMBL2756054 0.80 EIF4A3 (0.57) EIF4A3KIF11SCN10ALMNATRPA1
SCHEMBL5947744 0.79 EIF4A3 (0.53) EIF4A3KIF11SCN10ALMNATRPA1
SCHEMBL20416013 0.78 EIF4A3 (0.56) EIF4A3KIF11SCN10ALMNATRPA1
SCHEMBL12589464 0.78 BRD4 (0.56) EIF4A3KIF11SCN10ALMNATRPA1
SCHEMBL13561663 0.77 KIF11 (0.47) EIF4A3KIF11PTGS2CYP2A6KEAP1
SCHEMBL13160193 0.76 EIF4A3 (0.57) EIF4A3KIF11SCN10ALMNACDK5
SCHEMBL18596058 0.76 EIF4A3 (0.53) EIF4A3KIF11SCN10ALMNATRPA1
SCHEMBL12589456 0.74 EIF4A3 (0.56) EIF4A3KIF11SCN10AAURKADAPK3
SCHEMBL13024464 0.74 LMNA (0.60) EIF4A3KIF11KEAP1LMNAAURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11958873-B2 Proteasome activity enhancing compounds Kineta, Inc. (US) 2024-04-16 US disclosed
US-20230242557-A9 PROTEASOME ACTIVITY ENHANCING COMPOUNDS Kineta, Inc. 2023-08-03 US disclosed
US-20230242557-A9 PROTEASOME ACTIVITY ENHANCING COMPOUNDS Kineta, Inc. 2023-08-03 US disclosed
US-20230242557-A9 PROTEASOME ACTIVITY ENHANCING COMPOUNDS Kineta, Inc. 2023-08-03 US disclosed
US-20220298181-A1 PROTEASOME ACTIVITY ENHANCING COMPOUNDS PROTEOSTASIS THERAPEUTICS INC (US) 2022-09-22 US disclosed
US-11242361-B2 Proteasome activity enhancing compounds PROTEOSTASIS THERAPEUTICS, INC. (US) 2022-02-08 US disclosed
US-11242361-B2 Proteasome activity enhancing compounds PROTEOSTASIS THERAPEUTICS, INC. (US) 2022-02-08 US disclosed
US-20200308198-A1 PROTEASOME ACTIVITY ENHANCING COMPOUNDS PROTEOSTASIS THERAPEUTICS, INC. 2020-10-01 US disclosed
US-9850262-B2 Proteasome activity enhancing compounds PROTEOSTASIS THERAPEUTICS, INC. (US) 2017-12-26 US disclosed
US-9850262-B2 Proteasome activity enhancing compounds PROTEOSTASIS THERAPEUTICS, INC. (US) 2017-12-26 US disclosed
US-20140315792-A1 ANTI-VIRAL COMPOUNDS ABBOTT LABORATORIES 2014-10-23 US disclosed
US-20120220562-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2012-08-30 US disclosed
US-20120172290-A1 Anti-Viral Compounds ABBOTT LABORATORIES (US) 2012-07-05 US disclosed
US-20120115918-A1 Anti-Viral Compounds ABBOTT LABORATORIES (US) 2012-05-10 US disclosed
US-20120039848-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2012-02-16 US disclosed
US-20120004196-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2012-01-05 US disclosed
US-20110217261-A1 COMBINATION PHARMACEUTICAL AGENTS AS INHIBITORS OF HCV REPLICATION ENANTA PHARMACEUTICALS, INC. 2011-09-08 US disclosed
US-20110092415-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2011-04-21 US disclosed
US-20100317568-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2010-12-16 US disclosed
US-20100267634-A1 Anti-Viral Compounds Abbott Labaoratories (US) 2010-10-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100317568-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS EIF4A3 48/4885KIF11 3591/4885SCN10A 4583/4885
US-20100267634-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS EIF4A3 48/4885KIF11 3591/4885SCN10A 4583/4885
US-20120039848-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, SLC10A1, EIF2AK2 EIF4A3 62/4885KIF11 3339/4885SCN10A 4134/4885
US-20230242557-A9 PROTEASOME ACTIVITY ENHANCING COMPOUNDS PSMG3, PSMB1, PSMC1 EIF4A3 405/4885KIF11 3414/4885SCN10A 3337/4885
US-20110217261-A1 COMBINATION PHARMACEUTICAL AGENTS AS INHIBITORS OF HCV REPLICATION HAVCR2, EIF2AK2, MAVS EIF4A3 73/4885KIF11 3921/4885SCN10A 4226/4885
US-20120115918-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS EIF4A3 48/4885KIF11 3591/4885SCN10A 4583/4885
US-20120220562-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS EIF4A3 48/4885KIF11 3591/4885SCN10A 4583/4885
US-20140315792-A1 ANTI-VIRAL COMPOUNDS HAVCR2, EIF2AK2, MAVS EIF4A3 48/4885KIF11 3591/4885SCN10A 4583/4885
US-20110092415-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS EIF4A3 48/4885KIF11 3591/4885SCN10A 4583/4885
US-20220298181-A1 PROTEASOME ACTIVITY ENHANCING COMPOUNDS PSMG3, PSMB1, PSMC1 EIF4A3 405/4885KIF11 3414/4885SCN10A 3337/4885
US-11242361-B2 Proteasome activity enhancing compounds PSMG3, PSMB1, PSMC1 EIF4A3 405/4885KIF11 3414/4885SCN10A 3337/4885
US-20200308198-A1 PROTEASOME ACTIVITY ENHANCING COMPOUNDS PSMG3, PSMB1, PSMC1 EIF4A3 405/4885KIF11 3414/4885SCN10A 3337/4885
US-20120004196-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS EIF4A3 48/4885KIF11 3591/4885SCN10A 4583/4885
US-11958873-B2 Proteasome activity enhancing compounds PSMG3, PSMB1, PSMC1 EIF4A3 405/4885KIF11 3414/4885SCN10A 3337/4885
US-20120172290-A1 Anti-Viral Compounds HAVCR2, EIF2AK2, MAVS EIF4A3 48/4885KIF11 3591/4885SCN10A 4583/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.